Acriflavine and proflavine hemisulfate as potential antivirals by targeting MproArticle Published on 2022-12-012022-11-15 Journal: Bioorganic chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] ACF acriflavine activity addition anti-SARS-CoV-2 Antiviral antiviral target BHK-21 cell Compound Coronaviruses demonstrated effective drugs effort enzymatic assay experiment HCoV-OC43 in vitro Infection inhibited inhibitor inhibitors inhibitory activity M pro M(pro) inhibitor MPro Proflavine Proflavine hemisulfate Remdesivir Replication reported SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 virus SARS-CoV-2. Transcription Viral RNA [DOI] 10.1016/j.bioorg.2022.106185 PMC 바로가기
Transcriptomic analysis of the innate immune signatures of a SARS-CoV-2 protein subunit vaccine ZF2001 and an mRNA vaccine RRVSARS-CoV-2 단백질 소단위 백신 ZF2001 및 mRNA 백신 RRV의 타고난 면역 특징의 전사체 분석Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation Analysis Anti-viral antibody approach binding CD74 Cell comparable COVID-19 cytokine Cytokines early response elicited expression level expression of gene framework Gene Expression Genes immune response immune responses immunization innate immune innate immune response Innate immunity involved mapped MHC class mRNA mRNA vaccine neutralization Neutralization antibody Pattern recognition pattern recognition receptor Pattern recognition receptors post vaccination Protein subunit protein subunit vaccine PRRs RNA degradation robust SARS-CoV-2 SARS-CoV-2 protein subunit Subunit vaccine Tap1 titre titres Transcription transcriptional Transcriptome transcriptome sequencing Transcriptome sequencing. transcriptomic transduction Vaccine ZF2001 [DOI] 10.1080/22221751.2022.2059404 PMC 바로가기 [Article Type] Article
Discovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptorArticle Published on 2022-11-022022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] Antiviral antivirals binding C-terminal domain cell cultures compounds coronavirus Critical CTD disrupt Genome identify information isothermal titration calorimetry Ligand ligands N protein N-protein NMR nucleocapsid Protein reduced representing RNA SARS-CoV-2 nucleocapsid SARS-CoV-2 replication small molecule the N protein the SARS-CoV-2 the SARS-CoV-2 genome Transcription [DOI] 10.1038/s41598-022-22576-4 PMC 바로가기
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cellsArticle Published on 2022-11-012022-11-15 Journal: Acta pharmacologica Sinica [Category] COVID19(2023년), SARS, 진단, [키워드] 16HBE 16HBE cell 16HBE cells 6-O-angeloylplenolin ACE2 ACE2 expression addition administration Cell Centipeda Centipeda minima chemokine Chinese Compound conducted COVID-19 CX3CL1 CXCL13 dataset demonstrated downregulated entry of SARS-CoV-2 enzyme evaluated expression gene encoding HLF IL-6 inhibited inhibitor Interaction lung epithelial cell Lung epithelial cells lung tissue lung tissues mice modulate parental pathogen phosphorylated positively correlated promoter PROTECT Protein pseudovirus receptor reduced regulate Regulation S protein SARS-CoV-2 SARS-COV-2 infection screened STAT3 STAT3. stimulated suppressed target cells tested TFS Transcription transcription factor transfected with [DOI] 10.1038/s41401-022-00906-6 PMC 바로가기
Repurposing of the herbal formulations: molecular docking and molecular dynamics simulation studies to validate the efficacy of phytocompounds against SARS-CoV-2 proteinsArticle Published on 2022-11-012022-11-16 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] Analysis binding affinity can be used Casuarinin Compound Corilagin COVID-19 docking result effective Efficacy evaluate function Herbal in silico Interaction investigated involved Ligand liquorice MD simulation molecular docking molecular dynamics Molecular dynamics simulation New polyherbal formulations Protein Proteins receptor receptor proteins Replication repurposing Result SARS-CoV-2 SARS-CoV-2 protein scored stability suggested the SARS-CoV-2 Traditional medicine Transcription Treatment Trial Validation. virus was performed [DOI] 10.1080/07391102.2021.1922095 PMC 바로가기
Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease VariantsArticle Published on 2022-10-302022-11-16 Journal: Journal of Molecular Biology [Category] COVID19(2023년), SARS, 변종, [키워드] Affect analysis analyzed biochemically bioinformatics catalytic caused changed characterization characterized cleavage Combination conserved coronavirus Coronaviruses Course COVID-19 pandemic domain drug design effort endoribonuclease endoribonuclease. EndoU evade Evolution facilitate Genome help Host immune response in vivo inactive increase in innate immune response middle monomeric Mutation N-terminal nonstructural proteins novel coronavirus SARS-CoV-2 Nsp15 oligomerization pandemic Patient prevalent Protein residue RNA SARS-CoV-2 SARS-CoV-2 sequence Sequencing Transcription triggering understanding variant viral genome Viral protein viral replication virus wild type [DOI] 10.1016/j.jmb.2022.167796 PMC 바로가기
The impact of COVID-19 on implementation of mass testing, treatment and tracking of malaria in rural communities in Ghana: A qualitative studyArticle Published on 2022-10-132022-11-15 Journal: PLoS ONE [Category] 진단, [키워드] addition affected analysed Analysis children Community Complication conducted Coverage COVID-19 COVID-19 pandemic Effect eight English finding group Health health worker identify implementation increase in Intervention introduced malaria mass methodology observation pandemic parent participant public health respond responsible Transcription translated treat Treatment Volunteer volunteers was used were recorded [DOI] 10.1371/journal.pone.0275976 PMC 바로가기
Protocol for characterizing the inhibition of SARS-CoV-2 infection by a protein of interest in cultured cellsArticle Published on 2022-10-042022-11-15 Journal: STAR protocols [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] Antiviral candidate Cell Biology Cell-based Assays cells Complete cultured cell cultured cells example Microbiology Molecular biology MUC1 Nucleocapsid gene Protein Protein Bbiochemistry. protocol quantification replication-competent SARS-CoV-2 SARS-CoV-2 SARS-COV-2 infection Transcription viral infection Virus-like particle [DOI] 10.1016/j.xpro.2022.101802 PMC 바로가기
Toehold-controlled ligation and transcription for accurate COVID-19 genotyping정확한 COVID-19 유전자형 분석을 위한 발가락 제어 결찰 및 전사Article Published on 2022-10-012022-09-11 Journal: Analytical biochemistry [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] approach Chain Reaction contagious coronavirus disease Coronavirus disease 2019 COVID-19 feature genotyping global pandemic in vitro transcription isothermal Ligase Ligase chain reaction linear Mutation point-of-care probe risk SARS-CoV-2 SARS-CoV-2 variant SNV SNVs specificity Toehold-mediated strand displacement reaction. Transcription variant virus [DOI] 10.1016/j.ab.2022.114803 PMC 바로가기 [Article Type] Article
Recent clinical findings on the role of kinase inhibitors in COVID-19 managementCOVID-19 관리에서 키나제 억제제의 역할에 대한 최근 임상 결과Review Published on 2022-10-012022-09-11 Journal: Life sciences [Category] 변종, 신약개발, 임상, 치료제, [키워드] activator affected alleviate Anti-inflammatory anti-viral effects antiviral agent Antiviral agents BTK clinical evidence Clinical finding Clinical practice clinical trial Complication complications Consequences coronavirus disease COVID-19 COVID-19 patient COVID-19 patients CRS cytokine release storm drug Efficacy glycogen synthase GSK-3 highly pathogenic inhibitor inhibitors JAK/STAT janus Janus kinase kinase Kinase inhibitor kinase inhibitors kinases management MAPK Novel coronavirus novel coronavirus disease outbreak p38 MAPK. pandemic paradigm shift performed pharmacological pharmacological intervention protein kinase recent Signaling STAT therapy Transcription trials Viral load [DOI] 10.1016/j.lfs.2022.120809 PMC 바로가기 [Article Type] Review